Host-induced epidemic spread of the cholera bacterium

被引：370

作者：

Merrell, DS

Butler, SM

Qadri, F

Dolganov, NA

Alam, A

Cohen, MB

Calderwood, SB

Schoolnik, GK

Camilli, A ^{[1
]}

机构：

[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

[2] Int Ctr Diarrhoeal Dis Res, Dhaka 1212, Bangladesh

[3] Stanford Univ, Sch Med, Beckman Ctr, Stanford, CA 94305 USA

[4] Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA

[5] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[6] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

NATURE | 2002年 / 417卷 / 6889期

关键词：

D O I：

10.1038/nature00778

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The factors that enhance the transmission of pathogens during epidemic spread are ill defined. Water-borne spread of the diarrhoeal disease cholera occurs rapidly in nature, whereas infection of human volunteers with bacteria grown in vitro is difficult in the absence of stomach acid buffering(1). It is unclear, however, whether stomach acidity is a principal factor contributing to epidemic spread(2). Here we report that characterization of Vibrio cholerae from human stools supports a model whereby human colonization creates a hyperinfectious bacterial state that is maintained after dissemination and that may contribute to epidemic spread of cholera. Transcriptional profiling of V. cholerae from stool samples revealed a unique physiological and behavioural state characterized by high expression levels of genes required for nutrient acquisition and motility, and low expression levels of genes required for bacterial chemotaxis.

引用

页码：642 / 645

页数：4

共 18 条

[1] Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection [J].