Tbx5 and the retinotectum projection

被引：199

作者：

Koshiba-Takeuchi, K

Takeuchi, JK

Matsumoto, K

Momose, T

Uno, K

Hoepker, V

Ogura, K

Takahashi, N

Nakamura, H

Yasuda, K

Ogura, T

机构：

[1] Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300101, Japan

[2] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[3] Tohoku Univ, Dept Mol Neurobiol, Sendai, Miyagi 98077, Japan

来源：

SCIENCE | 2000年 / 287卷 / 5450期

关键词：

D O I：

10.1126/science.287.5450.134

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dorsal and ventral aspects of the eye are distinct from the early stages of development. The developing eye cup grows dorsally, and the choroidal fissure is formed on its ventral side. Retinal axone from the dorsal and ventral retina project to the ventral and dorsal tectum, respectively. Misexpression of the Tbx5 gene induced dorsalization of the ventral side of the eye and altered projections of retinal ganglion cell axons. Thus, Tbx5 is involved in eye morphogenesis and is a topographic determinant of the visual projections between retina and tectum.

引用

页码：134 / 137

页数：4

共 37 条

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