Is the platelet lowering activity of anagrelide mediated by its major metabolite 2-amino-5,6-dichloro-3,4-dihydroquinazoline (RL603)?

被引：13

作者：

Erusalimsky, JD ^{[1
]}

Hong, Y

Franklin, R

机构：

[1] Univ Coll, Dept Med, BHF Labs, London, England

[2] Shire Pharmaceut Dev Ltd, Basingstoke, Hants, England

来源：

EXPERIMENTAL HEMATOLOGY | 2002年 / 30卷 / 07期

关键词：

D O I：

10.1016/S0301-472X(02)00870-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：625 / 626

页数：2

共 4 条

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EXPERIMENTAL HEMATOLOGY, 2001, 29 (12) :1417-1424

[2] Megakaryocytic differentiation is accompanied by a reduction in cell migratory potential [J].

Mathur, A ;

Hong, Y ;

Martin, JF ;

Erusalimsky, JD .

BRITISH JOURNAL OF HAEMATOLOGY, 2001, 112 (02) :459-465

[3] ANALYSIS OF THE MECHANISM OF ANAGRELIDE-INDUCED THROMBOCYTOPENIA IN HUMANS [J].

MAZUR, EM ;

ROSMARIN, AG ;

SOHL, PA ;

NEWTON, JL ;

NARENDRAN, A .

BLOOD, 1992, 79 (08) :1931-1937

[4]

McCarty JM, 2000, BLOOD, V96, p743A

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