An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits

被引：65

作者：

Dan, B

Hagit, C

Lily, N

Ebstein, RP ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Scheinfeld Ctr Human Genet Social Sci, Dept Psychol, Jerusalem, Israel

[2] Herzog Hosp, Jerusalem, Israel

[3] Soroka Med Ctr, Rheumat Dis Unit, Dept Med, Beer Shera, Israel

[4] Minist Hlth, Mental Hlth Ctr, Anxiety & Stress Res Unit, Beer Sheva, Israel

[5] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Epidemiol, Beer Sheva, Israel

来源：

MOLECULAR PSYCHIATRY | 2004年 / 9卷 / 08期

关键词：

D O I：

10.1038/sj.mp.4001506

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibromyalgia (FMS) is a common syndrome consisting of diffuse aching, pain, or stiffness in the muscles or joints, accompanied by multiple tender points on examination. FMS patients are characterized by an atypical personality profile, high on harm avoidance and low on novelty seeking. The current study showed a decreased frequency in FMS of a dopamine D4 receptor polymorphism, the 7 repeat, associated in some studies with novelty seeking.

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页码：730 / 731

页数：2

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