CHEMOTHERAPY Adding oxaliplatin to the equation

被引:2
作者
Benson, B. [1 ]
机构
[1] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USA
关键词
INDIVIDUAL PATIENT DATA; III COLON-CANCER; ADJUVANT TREATMENT; STAGE-II; FLUOROURACIL; LEUCOVORIN; SURVIVAL;
D O I
10.1038/nrclinonc.2009.162
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pooled analyses from the Adjuvant Treatment of Colon Cancer trial suggest that most patients with stage III colon cancer develop recurrence within the first 3 years following treatment. Improved disease-free survival and improved overall survival were observed for such patients who were treated with adjuvant combination therapy of 5-fluorouracil, leucovorin and oxaliplatin versus those treated with 5-fluorouracil and leucovorin.
引用
收藏
页码:620 / 622
页数:3
相关论文
共 9 条
[1]   Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer [J].
Andre, T ;
Boni, C ;
Mounedji-Boudiaf, L ;
Navarro, M ;
Tabernero, J ;
Hickish, T ;
Topham, C ;
Zaninelli, M ;
Clingan, P ;
Bridgewater, J ;
Tabah-Fisch, I ;
de Gramont, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (23) :2343-2351
[2]   Improved Overall Survival With Oxaliplatin, Fluorouracil, and Leucovorin As Adjuvant Treatment in Stage II or III Colon Cancer in the MOSAIC Trial [J].
Andre, Thierry ;
Boni, Corrado ;
Navarro, Matilde ;
Tabernero, Josep ;
Hickish, Tamas ;
Topham, Clare ;
Bonetti, Andrea ;
Clingan, Philip ;
Bridgewater, John ;
Rivera, Fernando ;
de Gramont, Aimery .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (19) :3109-3116
[3]  
Engstrom Paul F, 2007, J Natl Compr Canc Netw, V5, P884
[4]   Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07 [J].
Kuebler, J. Philip ;
Wieand, H. Samuel ;
O'Connell, Michael J. ;
Smith, Roy E. ;
Colangelo, Linda H. ;
Yothers, Greg ;
Petrelli, Nicholas J. ;
Findlay, Michael P. ;
Seay, Thomas E. ;
Atkins, James N. ;
Zapas, John L. ;
Goodwin, J. Wendall ;
Fehrenbacher, Louis ;
Ramanathan, Ramesh K. ;
Conley, Barbara A. ;
Flynn, Patrick J. ;
Soori, Gamini ;
Colman, Lauren K. ;
Levine, Edward A. ;
Lanier, Keith S. ;
Wolmark, Norman .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (16) :2198-2204
[5]   Clinical Trial Designs for Predictive Biomarker Validation: Theoretical Considerations and Practical Challenges [J].
Mandrekar, Sumithra J. ;
Sargent, Daniel J. .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (24) :4027-4034
[6]   Evidence for Cure by Adjuvant Therapy in Colon Cancer: Observations Based on Individual Patient Data From 20,898 Patients on 18 Randomized Trials [J].
Sargent, Daniel ;
Sobrero, Alberto ;
Grothey, Axel ;
O'Connell, Michael J. ;
Buyse, Marc ;
Andre, Thierry ;
Zheng, Yan ;
Green, Erin ;
Labianca, Roberto ;
O'Callaghan, Chris ;
Seitz, Jean Francois ;
Francini, Guido ;
Haller, Daniel ;
Yothers, Greg ;
Goldberg, Richard ;
de Gramont, Aimery .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (06) :872-877
[7]   End points for colon cancer adjuvant trials: Observations and recommendations based on individual patient data from 20,898 patients enrolled onto 18 Randomized trials from the ACCENT group [J].
Sargent, Daniel J. ;
Patiyil, Smitha ;
Yothers, Greg ;
Haller, Daniel G. ;
Gray, Richard ;
Benedetti, Jacqueline ;
Buyse, Marc ;
Labianca, Roberto ;
Seitz, Jean Francois ;
O'Callaghan, Christopher J. ;
Francini, Guido ;
Grothey, Axel ;
O'Connell, Michael ;
Catalano, Paul J. ;
Kerr, David ;
Green, Erin ;
Wieand, Harry S. ;
Goldberg, Richard M. ;
de Gramont, Aimery .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (29) :4569-4574
[8]   Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: Individual patient data from 20,898 patients on 18 randomized trials [J].
Sargent, DJ ;
Wieand, HS ;
Haller, DG ;
Gray, R ;
Benedetti, JK ;
Buyse, M ;
Labianca, R ;
Seitz, JF ;
O'Callaghan, CJ ;
Francini, G ;
Grothey, A ;
O'Connell, M ;
Catalano, PJ ;
Blanke, CD ;
Kerr, D ;
Green, E ;
Wolmark, N ;
Andre, T ;
Goldberg, RM ;
De Gramont, A .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (34) :8664-8670
[9]  
WOLMARK N, 2008, J CLIN ONCOL S, V26, P4005