The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems

被引：67

作者：

de Lecea, L ^{[1
]}

Sutcliffe, JG ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 56卷 / 5-6期

关键词：

Leptin; neuropeptide Y; perifornical area; lateral hypothalamus; food consumption; obesity;

D O I：

10.1007/s000180050446

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hypothalamus regulates diverse physiological functions, including the control of energy metabolism, circadian rhythms, stress and anxiety, sexual and reproductive behaviors. An overview of the most prevalent hypothalamus-enriched mRNAs revealed that this area of the brain specializes in producing intercellular signaling molecules. Two new secreted peptides derived from a single neuropeptide precursor, named hypocretins and orexins by two different groups, are synthesized in a small set of neurons in the perifornical area of the hypothalamus. Intracerebroventricular injection of the hypocretins/orexins increases food consumption in rats. Here we review recent progress in identifying: the role of the hypocretins/orexins in the control of energy balance and in other physiological systems.

引用

页码：473 / 480

页数：8

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