5-HT1D and 5-HT2B receptors mediate contraction of smooth muscle in human small intestine

被引：14

作者：

Borman, RA ^{[1
]}

Burleigh, DE ^{[1
]}

机构：

[1] UNIV LONDON QUEEN MARY & WESTFIELD COLL, DEPT PHARMACOL, LONDON E1 4NS, ENGLAND

来源：

RECEPTOR CLASSIFICATION: THE INTEGRATION OF OPERATIONAL, STRUCTURAL, AND TRANSDUCTIONAL INFORMATION | 1997年 / 812卷

关键词：

D O I：

10.1111/j.1749-6632.1997.tb48182.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In conclusion, 5-HT has been shown to contract both circular and longitudinal muscle layers of human terminal ileum. By the use of selective antagonists, the receptors mediating these actions have been identified. In the circular muscle of human small intestine, 5-HT-induced contraction is mediated via a receptor of the 5-HT(1D) sub-type, whereas a receptor of the 5-HT-(2B) sub-type mediates the contractile response to 5-HT of longitudinal muscle layers.

引用

页码：222 / 223

页数：2