Synthesis of antioxidative and anti-inflammatory drugs glucoconjugates

被引：56

作者：

Uhrig, RK

Picard, MA

Beyreuther, K

Wiessler, M

机构：

[1] Zentrum Mol Biol, D-69120 Heidelberg, Germany

[2] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany

来源：

CARBOHYDRATE RESEARCH | 2000年 / 325卷 / 01期

关键词：

glycosylation; antioxidants; anti-inflammatory drugs; glucose transporter; blood-brain barrier; cancer; Alzheimer's disease;

D O I：

10.1016/S0008-6215(99)00311-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucoconjugates of (+/-)-ibuprofen, (+/-)-alpha-tocopherol (vitamin E), gentisic acid, gallic acid, 2,6-bis(tert-butyl)-4-thiophenol, and N-acetyl-L-cysteine were prepared with the objective of increasing the bioavailability of such antioxidant and anti-inflammatory drugs. The O-glucosides were synthesized using benzylated alpha-D-glucopyranosyl trichloracetimidate as glycosyl donor. For the synthesis of the S-glucosides, the glycosyl donor 1,2,3,4,6-penta-O-acetyl-beta-D-glucopyranose provided higher yields than the corresponding O-acetylated imidate. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：72 / 80

页数：9

共 31 条

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