Minocycline and ethylenediaminetetraacetate for the prevention of recurrent vascular catheter infections

被引：72

作者：

Raad, I

Buzaid, A

Rhyne, J

Hachem, R

Darouiche, R

Safar, H

Albitar, M

Sherertz, RJ

机构：

[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT MELANOMA SARCOMA,HOUSTON,TX 77030

[2] UNIV TEXAS,MD ANDERSON CANCER CTR,DIV LAB MED,HOUSTON,TX 77030

[3] BAYLOR COLL MED,INFECT DIS SECT,HOUSTON,TX 77030

[4] VET AFFAIRS MED CTR,HOUSTON,TX 77030

[5] WILMINGTON HLTH ASSOCIATES,WILMINGTON,NC

[6] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DIV INFECT DIS,WINSTON SALEM,NC

来源：

CLINICAL INFECTIOUS DISEASES | 1997年 / 25卷 / 01期

关键词：

D O I：

10.1086/514518

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three patients with recurrent vascular catheter-related bacteremia were successfully treated by allowing a solution of minocycline and ethylenediaminetetraacetate (EDTA) to dwell in the lumen of the indwelling catheter or by coating polyurethane catheters with minocycline/EDTA and hushing the lumen daily with the same solution, In vitro and in vivo experiments showed that minocycline/EDTA may have broad-spectrum antimicrobial activity, may have optimal anticoagulant activity, and may be highly efficacious in preventing catheter colonization.

引用

页码：149 / 151

页数：3

共 12 条

[1] ANTIBIOTIC PENETRATION OF AND BACTERICIDAL ACTIVITY WITHIN ENDOTHELIAL-CELLS [J].