Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles

被引：110

作者：

Kawano, Kumi

Watanabe, Masato

Yamamoto, Tatsuhiro

Yokoyama, Masayuki

Opanasopit, Praneet

Okano, Teruo

Maitani, Yoshie

机构：

[1] Hoshi Univ, Inst Med Chem, Shinagawa Ku, Tokyo 1428501, Japan

[2] Kanagawa Acad Sci & Technol, KSP E 404, Takatsu Ku, Kawasaki, Kanagawa 2130012, Japan

[3] Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Shinjuku Ku, Tokyo 1628666, Japan

来源：

JOURNAL OF CONTROLLED RELEASE | 2006年 / 112卷 / 03期

关键词：

camptothecin; polymeric micelle; antitumor effect; biodistribution; colon; 26; tumor;

D O I：

10.1016/j.jconrel.2006.03.012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A water-insoluble antitumor agent, camptothecin (CPT) was successfully incorporated into polymeric micelles formed from poly(ethylene glycol)-poly(benzyl aspartate) block copolymers (CPT-loaded polymeric micelles). Antitumor effects and biodistribution of CPT-loaded micelles were evaluated in mice subcutaneously transplanted by colon 26 tumor cells. Tumor growth was significantly inhibited after a single i.v. injection of CPT-loaded polymeric micelles at doses of either 15 or 30 mg/kg. Efficacy of a single high-dose injection was comparable to low dose multiple injections. CPT loaded in polymeric micelles showed prolonged blood circulation and higher accumulation in tumors compared with CPT in solution. Polymeric micelle systems offer a stable and effective platform for cancer chemotherapy with CPT. (c) 2006 Elsevier B.V All rights reserved.

引用

页码：329 / 332

页数：4

共 19 条

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