Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146.

被引：30

作者：

Norman, BH ^{[1
]}

Dantzig, AH ^{[1
]}

Kroin, JS ^{[1
]}

Law, KL ^{[1
]}

Tabas, LB ^{[1
]}

Shepard, RL ^{[1
]}

Palkowitz, AD ^{[1
]}

Hauser, KL ^{[1
]}

Winter, MA ^{[1
]}

Sluka, JP ^{[1
]}

Starling, JJ ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(99)00610-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The benzothiophene LY329146 reverses the drug resistance phenotype in multidrug resistance protein (MRP1)-overexpressing cells when dosed in combination with MRP1-associated oncolytics doxorubicin and vincristine. Additionally, LY329146 inhibited MRP1-mediated uptake of the MRP1 substrate LTC, into membrane vesicles prepared from MRP1-overexpressing cells, (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3381 / 3386

页数：6

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