Risk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpura

被引：41

作者：

Hazzan, Rawi

Mukamel, Mashaand

Yacobovich, Joanne

Yaniv, Isaac

Tamary, Hannah

机构：

[1] Schneider Childrens Med Ctr Israel, Rabin Med Ctr, IL-49202 Petah Tiqwa, Israel

[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[3] Schneider Childrens Med Ctr Israel, Rheumatol Unit, Petah Tiqwa, Israel

[4] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[5] Schneider Childrens Med Ctr Israel, Div Hematol Oncol, Petah Tiqwa, Israel

[6] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

来源：

PEDIATRIC BLOOD & CANCER | 2006年 / 47卷 / 05期

关键词：

anti-nuclear antibody; children; ITP; SLE;

D O I：

10.1002/pbc.20970

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The risk of later development of systemic lupus erythematosus (SLE) in childhood idiopathic thrombocytopenic purpura (ITP) is currently unknown. We retrospectively evaluated the incidence and risk factors of this complication in 222 children with ITP who were followed for a mean of 4.2 +/- 4.9 years. During that time 3.6% of the children (8/222) developed SLE; all were females with positive anti-nuclear antibody (ANA), older (12.7 +/- 3.6 vs. 6.4 +/- 4.3 years old; P < 0.01), and were more likely to have chronic ITP (87.5 vs. 46%; P = 0.02), and had high titers of ANA. The majority of children with ITP who had a positive ANA (14/22, 64%) did not develop SLE. Pediatr Blood Cancer 2006;47:657-659. (c) 2006 Wiley-Liss, Inc.

引用

页码：657 / 659

页数：3

共 13 条

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