Expression of renal transforming growth factor-β and its receptors in a rat model of chronic cyclosporine-induced nephropathy

被引：10

作者：

Bing, P. ^{[1
]}

Maode, L. ^{[1
]}

Li, F. ^{[1
]}

Sheng, H. ^{[1
]}

机构：

[1] Sichuan Univ, W China Hosp, Dept Surg, Chengdu 610041, Peoples R China

来源：

TRANSPLANTATION PROCEEDINGS | 2006年 / 38卷 / 07期

关键词：

TUBULAR EXPRESSION; FACTOR-BETA(1); GROWTH-FACTOR-BETA-1; STIMULATION; DYSFUNCTION;

D O I：

10.1016/j.transproceed.2006.07.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective. We sought to detect expression of transforming growth factor-beta 1 (TGF-beta 1) as well as its receptors type I (TRI) and type II (TRII) in rat kidneys during chronic cyclosporine (CsA)-induced nephropathy. Methods. Twenty four rats were randomly divided into three experimental groups: group 1; NSD (control, n = 8) were administered a normal sodium diet, group 2; LSD (n = 8) were administered a low sodium diet, group 3; CsA (n = 8) were sodium-depleted rats administered Neoral by gastric gavage in a model of chronic CsA-induced nephropathy. TGF-beta 1, TRI, and TRII proteins, as well as TRI and TRII mRNAs were measured in the CsA-treated rat kidneys by immunohistochemistry and in situ hybridization, respectively. Serniquantitative results were shown by image analysis. Results. The expression of TGF-beta 1, TRI, TRII, TRI mRNA, and TRII mRNA were all increased in CsA-treated rat kidneys, compared with NSD or LSD (P < .05). Conclusion. Our study showed that the ligand of TGF-beta 1 and its receptors TRI, TRII were all up-regulated. It may be important inhibit the expression of TGF-beta 1 or its receptors in patients who suffer from chronic CsA-induced nephropathy.

引用

页码：2176 / 2179

页数：4

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