Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms

被引：34

作者：

Ide, S.

Kobayashi, H.

Ujike, H.

Ozaki, N.

Sekine, Y.

Inada, T.

Harano, M.

Komiyama, T.

Yamada, M.

Iyo, M.

Iwata, N.

Tanaka, K.

Shen, H.

Iwahashi, K.

Itokawa, M.

Minami, M.

Satoh, M.

Ikeda, K.

Sora, I.

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Psychobiol, Aoba Ku, Sendai, Miyagi 9808574, Japan

[2] Tokyo Inst Psychiat, Div Psychobiol, Tokyo, Japan

[3] Hiroshima Int Univ, Neuropharmacol Lab, Dept Pharmaceut Sci, Kure, Japan

[4] Kyoto Univ, Fac Pharmaceut Sci, Dept Mol Pharmacol, Kyoto 606, Japan

[5] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama, Japan

[6] Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi, Japan

[7] Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 43131, Japan

[8] Teikyo Univ, Sch Med, Ichihara Hosp, Dept Psychiat, Chiba, Japan

[9] Kurume Univ, Sch Med, Dept Neuropsychiat, Kurume, Fukuoka 830, Japan

[10] Natl Ctr Neurol & Psychiat, Div Psychiat, Natl Ctr Hosp Mental Nervous & Muscular Disorders, Tokyo, Japan

[11] NIMH, Dept Psychogeriatr, Natl Ctr Neurol & Psychiat, Tokyo, Japan

[12] Chiba Univ, Grad Sch Med, Dept Psychiat, Chiba, Japan

[13] Fujita Hlth Univ, Sch Med, Dept Psychiat, Aichi, Japan

[14] Azabu Univ, Hlth Adm Ctr, Kanagawa, Japan

[15] Tokyo Inst Psychiat, Schizophrenia Res Project, Tokyo, Japan

[16] Hokkaido Univ, Dept Pharmacol, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido, Japan

来源：

PHARMACOGENOMICS JOURNAL | 2006年 / 6卷 / 03期

关键词：

single-nucleotide polymorphism; human mu-opioid receptor; methamphetamine; dependence; psychosis;

D O I：

10.1038/sj.tpj.6500355

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Several studies indicate that the mu-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the mu-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2+G691C between control (n = 232) and MAP-dependent/psychotic patients (n = 128). There was also a significant association between IVS2+G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.

引用

页码：179 / 188

页数：10

共 49 条

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