Effects of chronic mild stress on the oxidative parameters in the rat brain

被引:223
作者
Lucca, Giancarlo [2 ]
Comim, Clarissa M. [2 ]
Valvassori, Samira S. [2 ]
Reus, Gislaine Z. [2 ]
Vuolo, Francieli [3 ]
Petronilho, Fabricia [3 ]
Dal-Pizzol, Felipe [3 ]
Gavioli, Elaine C. [2 ]
Quevedo, Joao [1 ,2 ]
机构
[1] Univ Extremo Sul Catarinense, UNASAU, PPGCS, Lab Neurociencias,Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil
[2] Univ Extremo Sul Catarinense, Inst Nacl Ciencia & Tecnol Translac Med, PPGCS, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil
[3] Univ Extremo Sul Catarinense, Lab Fisiopatol Expt, PPGCS, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil
关键词
Major depression; Chronic mild stress; Reactive oxygen species; Antioxidants activity; MAJOR DEPRESSIVE DISORDER; LIPID-PEROXIDATION; BEHAVIOR; DAMAGE;
D O I
10.1016/j.neuint.2009.01.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Major depression is characterized for symptoms at the psychological, behavioral and physiological levels. The chronic mild stress model has been used as an animal model of depression. The consumption of sweet food, locomotor activity, body weight, lipid and protein oxidation levels and superoxide dismutase and catalase activities in the rat hippocampus, prefrontal cortex and cortex were assessed in rats exposed to chronic mild stress. Our findings demonstrated a decrease on sweet food intake, no effect on locomotor activity, lack of body weight gain, increase in protein (prefrontal, hippocampus, striatum and cortex) and lipidic peroxidation (cerebellum and striatum), and an increase in catalase (cerebellum, hippocampus, striatum, cortex) and a decrease in superoxide dismutase activity (prefrontal, hippocampus, striatum and cortex) in stressed rats. In conclusion, our results support the idea that stress produces oxidants and an imbalance between superoxide dismutase and catalase activities that contributes to stress-related diseases, such as depression. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:358 / 362
页数:5
相关论文
共 33 条
[1]  
Abraham S, 2005, INDIAN J MED RES, V121, P111
[2]  
AEBI H, 1984, METHOD ENZYMOL, V105, P121
[3]  
BANNISTER JV, 1987, METHOD BIOCHEM ANAL, V32, P279
[4]   Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains [J].
Bekris, S ;
Antoniou, K ;
Daskas, S ;
Papadopoulou-Daifoti, Z .
BEHAVIOURAL BRAIN RESEARCH, 2005, 161 (01) :45-59
[5]   Antioxidative enzyme activities and lipid peroxidation in major depression:: alterations by antidepressant treatments [J].
Bilici, M ;
Efe, H ;
Köroglu, MA ;
Uydu, HA ;
Bekaroglu, M ;
Deger, O .
JOURNAL OF AFFECTIVE DISORDERS, 2001, 64 (01) :43-51
[6]   Assessing antidepressant activity in rodents: recent developments and future needs [J].
Cryan, JF ;
Markou, A ;
Lucki, I .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2002, 23 (05) :238-245
[7]   STRESSORS IN THE LEARNED HELPLESSNESS PARADIGM - EFFECTS ON BODY-WEIGHT AND CONDITIONED TASTE-AVERSION IN RATS [J].
DESS, NK ;
RAIZER, J ;
CHAPMAN, CD ;
GARCIA, J .
PHYSIOLOGY & BEHAVIOR, 1988, 44 (4-5) :483-490
[8]  
Durany N, 1999, EUR ARCH PSY CLIN N, V249, P68
[9]   Venlafaxine modulates depression-induced oxidative stress in brain and medulla of rat [J].
Eren, Ibrahim ;
Naziroglu, Mustafa ;
Demirdas, Arif ;
Celik, Omer ;
Uguz, A. Cihangir ;
Altunbasak, Ayse ;
Ozmen, Ismail ;
Uz, Efkan .
NEUROCHEMICAL RESEARCH, 2007, 32 (03) :497-505
[10]  
ESTERBAUER H, 1990, METHOD ENZYMOL, V186, P407