Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family

被引：155

作者：

Cichewicz, RH ^{[1
]}

Valeriote, FA

Crews, P

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif Santa Cruz, Inst Marine Sci, Santa Cruz, CA 95064 USA

[3] Josephine Ford Canc Ctr, Div Hematol & Oncol, Detroit, MI 48202 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 12期

关键词：

D O I：

10.1021/ol049503q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1) possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural similarities to the pederin family metabolites. The potent cytotoxicty and unique structural features of 1 make it a promising lead for therapeutic development.

引用

页码：1951 / 1954

页数：4

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