Sequence variation in 5' termini of rubella virus genomes: Changes affecting structure of the 5' proximal stem-loop

被引:2
作者
Johnstone, P
Whitby, JE
Bosma, T
Best, JM
Sanders, PG
机构
[1] UNIV SURREY,SCH BIOL SCI,MOL MICROBIOL GRP,GUILDFORD GU2 5XH,SURREY,ENGLAND
[2] UNITED MED & DENT SCH GUYS & ST THOMASS HOSP,DEPT VIROL,LONDON SE1 7EH,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1007/BF01718645
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Variation within a 523 nucleotide region proximal to the 5' terminus of seven rubella virus strains has been analysed. Compared to the Therien strain twenty sites of nucleotide variation have been identified, three of which are in the 5' untranslated region. Individual strains have between three and nine nucleotide differences, only three of which result in amino acid substitutions. TO-336 has a serine for threonine at amino acid (aa) 42 and CM arginine for histidine at aa 159. RA27/3 has arginine for lysine at aa 3 and serine for threonine at aa 42. Nucleotide differences which affect a stem-loop structure reported to be important for binding of host cell proteins have been identified.
引用
收藏
页码:2471 / 2477
页数:7
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