Predicting PTSD prospectively based on prior trauma history and immediate biological responses

被引：78

作者：

Delahanty, Douglas L.

Nugent, Nicole R.

机构：

[1] Kent State Univ, Dept Psychol, Kent, OH 44242 USA

[2] Northeastern Ohio Univ Coll Med & Pharm, NEOUCOM, Dept Psychol Psychiat, Akron, OH 44308 USA

来源：

PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER: A DECADE OF PROGRESS | 2006年 / 1071卷

关键词：

PTSD; cortisol; predictors; catecholamines; heart rate; trauma history;

D O I：

10.1196/annals.1364.003

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies examining the biopsychology of posttraumatic stress disorder (PTSD) have suggested that PTSD is characterized by alterations of the primary stress pathways: the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). More recent investigations point to the presence of these alterations soon after a traumatic event, leading researchers to suggest that acute biological responses may serve as risk or resilience factors for the development of PTSD. The present article reviews the evidence for early biological predictors of PTSD, with a focus on the role of prior trauma as a contributor to both hormonal abnormalities and increased risk for the development of PTSD following a subsequent trauma.

引用

页码：27 / 40

页数：14

共 66 条

[1] ONE BRIEF EXPOSURE TO A PSYCHOLOGICAL STRESSOR INDUCES LONG-LASTING, TIME-DEPENDENT SENSITIZATION OF BOTH THE CATALEPTIC AND NEUROCHEMICAL RESPONSES TO HALOPERIDOL [J].