Tumor angiogenesis: A physiological process or genetically determined?

被引：29

作者：

DAmore, PA ^{[1
]}

Shima, DT ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,CELL BIOL LAB,LONDON WC2A 3PX,ENGLAND

来源：

CANCER AND METASTASIS REVIEWS | 1996年 / 15卷 / 02期

关键词：

hypoxia; neovascularization; vascular endothelial growth factor; tumor suppressors; oncogenes;

D O I：

10.1007/BF00437473

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Continued tumor growth is dependent upon the growth of new blood vessels. This commentary reviews the mechanisms whereby tumors become vascularized and examines whether tumor angiogenesis is solely an example of a normal physiologic process or is part of the genetic program of the tumor. The likelihood that neovascularization of tumors combines both of these components, that is, utilizing tumor-specific elements as well as capacities common to all cells, is discussed.

引用

页码：205 / 212

页数：8

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