Flavoenzymes: diverse catalysts with recurrent features

被引:435
作者
Fraaije, MW [1 ]
Mattevi, A [1 ]
机构
[1] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy
关键词
D O I
10.1016/S0968-0004(99)01533-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many biochemical processes exploit the extraordinary versatility of flavoenzymes and their flavin cofactors, Flavoproteins are now known to have a variety of folding topologies but a careful examination of their structures suggests that there are recurrent features in their catalytic apparatus. The flavoenzymes that catalyse dehydrogenation reactions share a few invariant features in the hydrogen-bond interactions between their protein and flavin constituents. Similarly, the positioning of the reactive part of the substrate with respect to the cofactor is generally conserved. Modulation of substrate and cofactor reactivity and exact positioning of the substrate are key elements in the mode of action of these enzymes.
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页码:126 / 132
页数:7
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