Administration of Ginseng radix decreases nitric oxide synthase expression in the hippocampus of streptozotocin-induced diabetic rats

被引:15
作者
Chang, HK
Jang, MH
Lim, BV
Lee, TH
Shin, MC
Shin, MS
Kim, H
Kim, YP
Kim, EH
Kim, CJ
机构
[1] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul 130701, South Korea
[2] Korea Univ, Res Inst Sports Sci, Seoul, South Korea
[3] Hannam Univ, Dept Sport & Leisure Studies, Taejon, South Korea
[4] Semyung Univ, Coll Oriental Med, Dept Meridianol, Chungbuk, South Korea
来源
AMERICAN JOURNAL OF CHINESE MEDICINE | 2004年 / 32卷 / 04期
关键词
diabetes; Ginseng radix; nicotinamide adenine dinucleotide phosphate-diaphorase; nitric oxide synthase; hippocampus;
D O I
10.1142/S0192415X04002144
中图分类号
R [医药、卫生];
学科分类号
10 [医学];
摘要
Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). Alternation of NOS expression is implicated in the pathogenesis of numerous secondary complications of diabetes. Aqueous extract of Ginseng radix has traditionally been used for the various disorders including diabetes. In this study, the effect of Ginseng radix on the NOS expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Enhanced NOS expression was detected in the hippocampus of diabetic rats and administration of Ginseng radix suppressed NOS expression. Ginseng radix may aid the treatment of central nervous system complications in diabetes.
引用
收藏
页码:497 / 507
页数:11
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