A weighted estimating equation for missing covariate data with properties similar to maximum likelihood

被引:92
作者
Lipsitz, SR [1 ]
Ibrahim, JG
Zhao, LP
机构
[1] Med Univ S Carolina, Dept Biometry & Epidemiol, Charleston, SC 29425 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[3] Dana Farber Canc Inst, Boston, MA 02115 USA
[4] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA
关键词
generalized linear model; missing at random; missing completely at random; missing-data mechanism;
D O I
10.2307/2669931
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
In regression analysis, missing covariate data occurs often. A recent approach to analyzing such data is weighted estimating equations. With weighted estimating equations, the contribution to the estimating equation from a complete observation is weighted by the inverse probability of being observed. In this article we propose a weighted estimating equation that is almost identical to the maximum likelihood estimating equations. As such, we propose an EM-type algorithm to solve these weighted estimating equations. Although the weighted estimating equations are a special case of those proposed earlier by Robins et al., our EM-type algorithm to solve them is new. Similar to Robins and Ritov, we give the result that to obtain a consistent estimate of the regression parameters, either the missing-data mechanism or the distribution of thr missing data given the observed data must be correctly specified. We compare the weighted estimating equations to maximum likelihood via two examples, a simulation and an asymptotic study.
引用
收藏
页码:1147 / 1160
页数:14
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