Differential sulfations and epimerization define heparan sulfate specificity in nervous system development
被引:199
作者:
Bülow, HE
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, Ctr Neurobiol & Behav, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, Ctr Neurobiol & Behav, New York, NY 10032 USA
Bülow, HE
[1
]
Hobert, O
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, Ctr Neurobiol & Behav, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, Ctr Neurobiol & Behav, New York, NY 10032 USA
Hobert, O
[1
]
机构:
[1] Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, Ctr Neurobiol & Behav, New York, NY 10032 USA
Heparan sulfate proteoglycans (HSPG) are components of the extracellular matrix through which axons navigate to reach their targets. The heparan sulfate (HS) side chains of HSPGs show complex and differentially regulated patterns of secondary modifications, including sulfations of distinct hydroxyl groups and epimerization of an asymmetric carbon atom. These modifications endow the HSPG-containing extracellular matrix with the potential to code for an enormous molecular diversity. Attempting to decode this diversity, we analyzed C. elegans animals lacking three HS-modifying enzymes, glucuronyl C5-epimerase, heparan 60-sulfotransferase, and 20-sulfotransferase. Each of the mutant animals exhibit distinct as well as overlapping axonal and cellular guidance defects in specific neuron classes. We have linked individual HS modifications to two specific guidance systems, the sax-3/Robo and kal-1/Anosmin-1 systems, whose activity is dependent on different HS modifications in different cellular contexts. Our results demonstrate that the molecular diversity in HS encodes information that is crucial for different aspects of neuronal development.
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Bernfield, M
Götte, M
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Götte, M
Park, PW
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Park, PW
Reizes, O
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Reizes, O
Fitzgerald, ML
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Fitzgerald, ML
Lincecum, J
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Lincecum, J
Zako, M
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
Crawford, BE
Olson, SK
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
Olson, SK
Esko, JD
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
Esko, JD
Pinhal, MAS
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
机构:
Univ Calif San Diego, Dept Cellular & Mol Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Cellular & Mol Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Esko, JD
Selleck, SB
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Dept Cellular & Mol Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Bernfield, M
Götte, M
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Götte, M
Park, PW
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Park, PW
Reizes, O
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Reizes, O
Fitzgerald, ML
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Fitzgerald, ML
Lincecum, J
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
Lincecum, J
Zako, M
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USAHarvard Univ, Sch Med, Childrens Hosp, Div Dev & Newborn Biol, Boston, MA 02115 USA
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
Crawford, BE
Olson, SK
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
Olson, SK
Esko, JD
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
Esko, JD
Pinhal, MAS
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USAUniv Calif San Diego, Glycobiol Res & Training Ctr, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
机构:
Univ Calif San Diego, Dept Cellular & Mol Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Cellular & Mol Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
Esko, JD
Selleck, SB
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Diego, Dept Cellular & Mol Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA