Different levels of neuroprotection by two insulin-like growth factor-I splice variants

被引：53

作者：

Aperghis, M

Johnson, IP

Cannon, J

Yang, SY

Goldspink, G

机构：

[1] UCL Royal Free & Univ Coll, Sch Med, Dept Surg, London NW3 2PF, England

[2] UCL Royal Free & Univ Coll, Sch Med, Dept Anat & Dev Biol, London NW3 2PF, England

来源：

BRAIN RESEARCH | 2004年 / 1009卷 / 1-2期

基金：

英国惠康基金;

关键词：

adult; avulsion; facial nerve; IGF-I; MGF; motoneuron;

D O I：

10.1016/j.brainres.2004.02.049

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups. MGF is markedly more effective than the liver-type, systemic IGF-I for motoneuron survival, suggesting a major role for the peripheral target in adult neuronal maintenance and survival. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：213 / 218

页数：6

共 39 条

[1] Age, diet and injury affect the survival of facial motoneurons [J].