Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subfractions

被引:35
作者
Thomas, TR
Smith, BK
Donahue, OM
Altena, TS
James-Kracke, M
Sun, GY
机构
[1] Univ Missouri, Dept Nutr Sci, Columbia, MO 65211 USA
[2] Univ Missouri, Dept Biochem & Pharmacol, Columbia, MO 65211 USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2004年 / 53卷 / 06期
关键词
D O I
10.1016/j.metabol.2003.12.019
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The purpose of this study was to examine the effect of combining exercise with omega-3 fatty acids (n-3fa) supplementation on lipoprotein subfractions and associated enzymes. Subjects were 10 recreationally active males, aged 25 +/- 1.5 years (mean +/- SE), who supplemented n-3fa (60% eicosapentaenoic acid [EPA] and 40% docosahexaenoic [DHA]) at 4 g/d for 4 weeks. Before and after supplementation, subjects completed a 60-minute session of treadmill exercise at 60% Vo(2)max. Following a 24-hour diet and activity control period, blood was collected immediately before and after the exercise session to assess lipid variables: high-density lipoprotein cholesterol (HDL-C) and subfractions, low-density lipoprotein cholesterol (LDL-C) and subfractions and particle size, lecithin:cholesterol acyltransferase (LCAT) activity, and cholesterol ester transfer protein (CETP) activity. Supplementation with n-3fa alone increased total HDL-C and HDL2-C, while exercise alone increased total HDL-C, HDL3-C, and total LDL-C. LDL subfractions, particle size, and LCAT and CETP activities were not affected by supplementation. Combination treatment resulted in an additive effect for HDL3-C only and also increased LDL1-C versus baseline. LCAT and CETP activities were not affected by treatments. These results suggest that n-3fa supplementation or an exercise session each affect total HDL-C and subfractions but not LDL-C or subfractions. In addition, the combination of n-3fa and exercise may have additional effects on total HDL-C and LDL-C subfractions as compared to either treatment alone in active young men. (C) 2004 Elsevier Inc. All rights reserved.
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收藏
页码:749 / 754
页数:6
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