Carbon-11 labeled radioligands for imaging brain cannabinoid receptors

被引：24

作者：

Mathews, WB ^{[1
]}

Scheffel, U

Rauseo, PA

Ravert, HT

Frank, RA

Ellames, GJ

Herbert, JM

Barth, F

Rinaldi-Carmona, M

Dannals, RF

机构：

[1] Johns Hopkins Univ, Dept Radiol, Baltimore, MD 21287 USA

[2] Sanofi Synthelabo, Malvern, PA 19355 USA

[3] Sanofi Synthelabo, Alnwick NE66 2JH, Northd, England

[4] Sanofi Synthelabo, Montpellier 04, France

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2002年 / 29卷 / 06期

关键词：

antagonist; cannabinoid; carbon-11; CB1; mice; PET;

D O I：

10.1016/S0969-8051(02)00308-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Two radioligands, [C-11] SR149080 and its morpholino analog [C-11] SR149568, were synthesized by reaction of the respective phenolic precursors with [C-11] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptor's in mice with peak target to non-target ratios of 2.2 for [C-11] SR149080 and 1.6 for [C-11] SR149568 at 90 and 30 minutes post-injection respectively. The uptake of both tracers was blocked with a 1 mg/kg dose of SR141716A. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：671 / 677

页数：7

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