Ribosome synthesis in Saccharomyces cerevisiae

被引：655

作者：

Venema, J ^{[1
]}

Tollervey, D

机构：

[1] Vrije Univ Amsterdam, Bioctr Amsterdam, IMBW, Dept Biochem & Mol Biol, NL-1081 HV Amsterdam, Netherlands

[2] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

ANNUAL REVIEW OF GENETICS | 1999年 / 33卷

基金：

英国惠康基金;

关键词：

pre-rRNA processing; nucleolus; snoRNA; exonuclease; assembly;

D O I：

10.1146/annurev.genet.33.1.261

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The synthesis of ribosomes is one of the major metabolic pathways in all cells. In addition to around 75 individual ribosomal proteins and 4 ribosomal RNAs, synthesis of a functional eukaryotic ribosome requires a remarkable number of trans-acting factors. Here, we will discuss the recent, and often surprising, advances in our understanding of ribosome synthesis in the yeast Saccharomyces cerevisiae. These will underscore the unexpected complexity of eukaryotic ribosome synthesis.

引用

页码：261 / 311

页数：51

共 208 条

[1] RNase III cleaves eukaryotic preribosomal RNA at a U3 snoRNP-dependent site [J].