Neuroprotective effect of hypoxic preconditioning: Phenomenon and mechanisms

被引：15

作者：

Kulinskii, VI ^{[1
]}

Minakina, LN ^{[1
]}

Gavrilina, TV ^{[1
]}

机构：

[1] Irkutsk State Med Univ, Dept Pharmacol, Dept Biochem, Irkutsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 02期

关键词：

hypoxic preconditioning; cerebral ischemia; A-receptors; hypothermia;

D O I：

10.1023/A:1015575628235

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

We developed a new model of hypoxic preconditioning improving tolerance of complete global cerebral ischemia. The role of adenosine receptors in the realization of this effect and in the mechanisms of hypoxic tolerance is demonstrated. Preconditioning decreases of body temperature, which correlates with the neuroprotective effect, but this effect does not directly result from hypothermia.

引用

页码：202 / 204

页数：3

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