Role of the bed nucleus of the stria terminalis (BST) in the expression of conditioned fear

被引：32

作者：

Meloni, Edward G.

Jackson, Alexandra

Gerety, Lyle P.

Cohen, Bruce M.

Carlezon, William A., Jr.

机构：

[1] McLean Hosp, Belmont, MA 02478 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Belmont, MA 02478 USA

来源：

PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER: A DECADE OF PROGRESS | 2006年 / 1071卷

关键词：

anxiety; PTSD; BST; fear-potentiated startle; CREB; muscimol;

D O I：

10.1196/annals.1364.059

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Male Sprague-Dawley rats were trained and tested in the fear-potentiated startle (FPS) paradigm to examine the involvement of the bed nucleus of the stria terminalis (BST) in the expression of conditioned fear. Studies were designed to (a) detect physiological changes in the BST that might correlate with different levels of FPS expression and (b) determine if chemical inactivation of the BST with muscimol (1 ng) had any effect on FPS expression. The data suggest that the BST plays a role in the expression of conditioned fear and that GABA-mediated inhibition at this level may influence the level of this expression.

引用

页码：538 / 541

页数：4

共 6 条

[1]

de Olmos JS, 1999, ANN NY ACAD SCI, V877, P1

[2] The emotional brain, fear, and the amygdala [J].