Synthesis and trichomonacidal activity of perketals and hydroperoxides

被引：2

作者：

Cointeaux, L

Berrien, JF ^{[1
]}

Camuzat-Dedenis, B

Peyrou, V

Provot, O

Bories, C

Loiseau, PM

Mayrargue, J

机构：

[1] Fac Pharm Chatenay Malabry, Chim Organ Lab, UPRESA Biocis 8076, F-92296 Chatenay Malabry, France

[2] Fac Pharm Chatenay Malabry, Parasitol Lab, EA 398, F-92296 Chatenay Malabry, France

来源：

FARMACO | 2002年 / 57卷 / 06期

关键词：

perketals; peroxides; hydroperoxides; Trichomonas vaginalis;

D O I：

10.1016/S0014-827X(02)01238-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Some perketals were synthesized by the Dussault procedure using simple bromides and 2-methoxyprop-2-yl hydroperoxide. Treatment with acetic acid gave the corresponding hydroperoxides. Both perketals and hydroperoxides were tested in vitro as trichomonacidal agents. Most of them exhibited very good activities. Them most powerful compound was 2-methoxyprop-2-yl hexadec-1-yl peroxide which exhibited an IC50 value of 0.51 muM being 10 times more effective than the reference compound Metronidazole. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

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收藏

页码：457 / 462

页数：6

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