Successful discontinuation of fluconazole as secondary prophylaxis for cryptococcosis in AIDS patients responding to highly active antiretroviral therapy

被引：12

作者：

Sheng, WH ^{[1
]}

Hung, CC ^{[1
]}

Chen, MY ^{[1
]}

Hsieh, SM ^{[1
]}

Chang, SC ^{[1
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2002年 / 13卷 / 10期

关键词：

Cryptococcus neoformans; cryptococcosis; AIDS; highly active antiretroviral therapy; antifungal prophylaxis;

D O I：

10.1258/095646202760326462

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Seven AIDS patients with disseminated cryptococcosis who had had immune reconstitution following highly active antiretroviral therapy (HAART) had discontinued their secondary antifungal prophylaxis to prevent relapse of Cryptococcus neoformans infection. The median CD4+ count was 236 cells/muL (range, 117-404 cells/muL; mean, 247 cells/muL) and the plasma viral loads were undetectable in five patients at discontinuation of antifungal prophylaxis. No relapse of cryptococcosis was detected in these patients after a median observation duration of nine months (range, 5.5-4.1 months, mean, 14.6 months) following discontinuation. Our data and review of the literature suggest that discontinuation of fluconazole prophylaxis is safe in patients with reconstitution of immunity following initiation of HAART.

引用

页码：702 / 705

页数：4

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