Stereospecific synthesis of the anaesthetic levobupivacaine

被引：40

作者：

Adger, B ^{[1
]}

Dyer, U ^{[1
]}

Hutton, G ^{[1
]}

Woods, M ^{[1
]}

机构：

[1] CHIROSCIENCE,CAMBRIDGE CB4 4WE,ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 35期

关键词：

D O I：

10.1016/0040-4039(96)01357-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically pure (S)-Bupivacaine is synthesised from the chiral pool using cheap and readily available (S)-lysine. The key steps in this efficient synthesis include an oxidative de-amination and stereospecific ring closure to Form the pipecolamide core structure. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6399 / 6402

页数：4

共 14 条

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