Stereospecific synthesis of the anaesthetic levobupivacaine

被引:40
作者
Adger, B [1 ]
Dyer, U [1 ]
Hutton, G [1 ]
Woods, M [1 ]
机构
[1] CHIROSCIENCE,CAMBRIDGE CB4 4WE,ENGLAND
关键词
D O I
10.1016/0040-4039(96)01357-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Enantiomerically pure (S)-Bupivacaine is synthesised from the chiral pool using cheap and readily available (S)-lysine. The key steps in this efficient synthesis include an oxidative de-amination and stereospecific ring closure to Form the pipecolamide core structure. Copyright (C) 1996 Elsevier Science Ltd
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页码:6399 / 6402
页数:4
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