Persistence of antibody and immunologic memory in children immunized with hepatitis B vaccine at birth

被引：25

作者：

Seto, D

West, DJ

Loli, VA

机构：

[1] Kapiolani Med Ctr Women & Children, Honolulu, HI 96826 USA

[2] Vaccine Dev & Evaluat, N Wales, PA USA

[3] Merck Res Labs, West Point, PA USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2002年 / 21卷 / 08期

关键词：

hepatitis B; hepatitis B vaccine; booster vaccination; antibody persistence; immunologic memory;

D O I：

10.1097/00006454-200208000-00021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Forty-two healthy children immunized with a course of hepatitis B vaccine beginning at birth were tested at 6 years of age for persistence of anti-hepatitis B antibody (anti-HBs) and then given a booster dose of vaccine. Although nearly one-half had become seronegative, all retained robust immunologic memory and rapidly regained a protective anti-HBs titer of at least 10 mIU/ml after booster vaccination.

引用

页码：793 / 795

页数：3

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