Long-term depression is reduced in cerebellar Purkinje cells of dystrophin-deficient mdx mice

被引：37

作者：

Anderson, JL ^{[1
]}

Head, SI ^{[1
]}

Morley, JW ^{[1
]}

机构：

[1] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia

来源：

BRAIN RESEARCH | 2004年 / 1019卷 / 1-2期

关键词：

muscular dystrophy; Duchenne; synaptic plasticity;

D O I：

10.1016/j.brainres.2004.06.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mdx (muscular dystrophy X-linked) mouse is a model for human Duchenne muscular dystrophy (DMD) and is characterized by the absence of the cytoskeletal protein dystrophin. Using a cerebellar slice preparation, we show that postsynaptically mediated long-term depression (LTD) is significantly reduced in mdx Purkinje cells, while presynaptically mediated paired-pulse facilitation (PPF) is normal. This disruption of LTD could contribute to the cognitive deficit in boys with Duchenne muscular dystrophy. Crown Copyright (C) 2004 Published by Elsevier B.V. All rights reserved.

引用

页码：289 / 292

页数：4

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