Regeneration following spinal cord injury, from experimental models to humans: where are we?

被引:14
作者
Di Giovanni, Simone [1 ]
机构
[1] Univ Tubingen, Lab Neuroregenerat & Repair, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany
关键词
molecular mechanism; regeneration; spinal cord injury (SCI); transplantation;
D O I
10.1517/14728222.10.3.363
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Regeneration in the adult CNS following injury is extremely limited. Traumatic spinal cord injury causes a permanent neurological deficit followed by a very limited recovery due to failed regeneration attempts. In fact, it is now clear that the spinal cord intrinsically has the potential to regenerate, but cellular loss and the presence of an inhibitory environment strongly limit tissue regeneration and functional recovery. The molecular mechanisms responsible for failed regeneration are starting to be unveiled. This gain in knowledge led to the design of therapeutic strategies aimed to limit the tissue scar, to enhance the proregeneration versus the inhibitory environment, and to replace tissue loss, including the use of stem cells. They have been very successful in several animal models, although results are still controversial in humans. Nonetheless, novel experimental approaches hold great promise for use in humans.
引用
收藏
页码:363 / 376
页数:14
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