Cloning of zebrafish T-box genes tbx15 and tbx18 and their expression during embryonic development

被引:41
作者
Begemann, G
Gibert, Y
Meyer, A
Ingham, PW
机构
[1] Univ Sheffield, Sch Med, Ctr Dev Genet, MRC Intercellular Signalling Grp,Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England
[2] Univ Konstanz, Dept Biol, D-78464 Constance, Germany
基金
英国生物技术与生命科学研究理事会;
关键词
T-box; tbx15; tbx18; limb development; neurocranium; somites; paraxial mesoderm; heart; zebrafish;
D O I
10.1016/S0925-4773(02)00040-0
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Members of the T-box (tbx) gene family encode developmentally regulated transcription factors, several of which are implicated in human hereditary diseases. We have cloned the paralogous genes tbx15 and tbx18 in zebrafish and have characterised their expression in detail. tbx15 is expressed in paraxial head mesenchyme and its derivatives, the extraocular and jaw musculature and the posterior neurocranium. Further areas of tbx15 expression are in the anterior somitic mesoderm, in periocular mesenchyme and in the pectoral an mesenchyme throughout larval development. Areas of strong tbx18 expression are found in the developing somitic and presomitic mesoderm, in the heart and in pectoral fin mesenchyme, as well as the ventral neuroectoderm and the developing palate. Both genes exhibit particular differences in expression compared to their murine orthologs. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:137 / 141
页数:5
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