Systemic infection of avian influenza A virus H5N1 subtype in humans

被引：65

作者：

Zhang, Zengfeng ^{[2
,3
,4
]}

Zhang, Jinxia ^{[2
,3
]}

Huang, Kai ^{[2
,3
]}

Li, Kang-Sheng ^{[4
]}

Yuen, Kwok-Yung ^{[2
,3
]}

Guan, Yi ^{[2
,3
,4
]}

Chen, Honglin ^{[2
,3
,4
]}

Ng, Wai Fu ^{[1
]}

机构：

[1] Princess Margaret Hosp, Dept Pathol, Hosp Author, Lai Chi Kok, Hong Kong, Peoples R China

[2] Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Pokfulam, Hong Kong, Peoples R China

[3] Univ Hong Kong, Res Ctr Infect & Immunol, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China

[4] Shantou Univ, Coll Med, Int Inst Infect & Immun, Shantou, Guangdong, Peoples R China

来源：

HUMAN PATHOLOGY | 2009年 / 40卷 / 05期

关键词：

Avian influenza A virus; H5N1; subtype; Human infection; Tissue tropism; Immunohistochemistry; PATHOLOGY;

D O I：

10.1016/j.humpath.2008.08.015

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depiction, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：735 / 739

页数：5

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