Osteogenesis imperfecta and malignant hyperthermia - Is there a relationship?

被引：45

作者：

Porsborg, P

Astrup, G

Bendixen, D

Lund, AM

Ording, H

机构：

[1] UNIV COPENHAGEN,HERLEV HOSP,DEPT ANAESTHESIOL,DANISH MALIGNANT HYPERTHERMIA REGISTER,DK-2730 HERLEV,DENMARK

[2] ARHUS KOMMUNEHOSP,DEPT ANAESTHESIOL,COPENHAGEN,DENMARK

[3] RIGSHOSP,DEPT PEDIAT,DIV CLIN GENET,DK-2100 COPENHAGEN,DENMARK

来源：

ANAESTHESIA | 1996年 / 51卷 / 09期

关键词：

anaesthetics; intravenous; hyperthermia; malignant; complications; osteogenesis imperfecta;

D O I：

10.1111/j.1365-2044.1996.tb12619.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We describe a patient with osteogenesis imperfecta who developed tachycardia, metabolic and respiratory acidosis (pH 7.14, PCO2 8.4 kPa, BE -8.5 mmol.l(-1)) and hyperthermia up to 40 degrees C during anaesthesia with barbiturates, fentanyl, pancuronium, and nitrous oxide. Malignant hyperthermia was suspected and the patient treated accordingly. Two years later the in-vitro contracture test for malignant hyperthermia was completely normal. We conclude that hypermetabolism in patients with osteogenesis imperfecta is due to unknown mechanisms other than malignant hyperthermia.

引用

页码：863 / 865

页数：3

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