Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells

被引：176

作者：

Meisse, D ^{[1
]}

Van de Casteele, M

Beauloye, C

Hainault, I

Kefas, BA

Rider, MH

Foufelle, F

Hue, L

机构：

[1] Univ Louvain, Sch Med, Hormone & Metab Res Unit, Brussels, Belgium

[2] Christian Duve Int Inst Mol & Cellular Pathol, Brussels, Belgium

[3] Free Univ Brussels, Diabet Res Ctr, Juvenile Diabet Res Ctr Beta Cell Therapy Europe, Brussels, Belgium

[4] INSERM, Ctr Biomed Cordeliers, U465, F-75270 Paris 06, France

来源：

FEBS LETTERS | 2002年 / 526卷 / 1-3期

基金：

澳大利亚研究理事会;

关键词：

AICA-riboside; AMP-activated protein kinase; apoptosis; c-Jun; N-terminal kinase; hepatocyte;

D O I：

10.1016/S0014-5793(02)03110-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this work was to study the effect of a sustained activation of AMP-activated protein kinase (AMPK) on liver cell survival. AMPK activation was achieved by incubating FTO2B cells with AICA-riboside, which is transformed into ZMP, an AMP analogue, or by adenoviral transfection of hepatocytes with a constitutively active form of AMPK. Prolonged AMPK activation triggered apoptosis and activated c-Jun N-terminal kinase (JNK) and caspase-3. Experiments with iodotubercidin, dicoumarol and z-VAD-fmk, which inhibited AMPK, JNK and caspase activation, respectively, supported the notion that prolonged AMPK activation in liver cells induces apoptosis through an activation pathway that involves JNK and caspase-3. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：38 / 42

页数：5

共 26 条

[1] The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes [J].

Blázquez, C ;

Geelen, MJH ;

Velasco, G ;

Guzmán, M .

FEBS LETTERS, 2001, 489 (2-3) :149-153

[2] PURIFICATION AND CHARACTERIZATION OF THE AMP-ACTIVATED PROTEIN-KINASE - COPURIFICATION OF ACETYL-COA CARBOXYLASE KINASE AND 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE KINASE-ACTIVITIES [J].

CARLING, D ;

CLARKE, PR ;

ZAMMIT, VA ;

HARDIE, DG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1989, 186 (1-2) :129-136

[3] Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and p21-activated kinase 2 [J].

Chan, WH ;

Yu, JS ;

Yang, SD .

BIOCHEMICAL JOURNAL, 2000, 351 :221-232

[4] c-Jun NH2-terminal kinase activation leads to a FADD-dependent but Fas ligand-independent cell death in Jurkat T cells [J].

Chen, Y ;

Lai, MZ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (11) :8350-8357

[5] Serine/threonine protein kinases and apoptosis [J].

Cross, TG ;

Scheel-Toellner, D ;

Henriquez, NV ;

Deacon, E ;

Salmon, M ;

Lord, JM .

EXPERIMENTAL CELL RESEARCH, 2000, 256 (01) :34-41

[6] AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes [J].

Foretz, M ;

Carling, D ;

Guichard, C ;

Ferré, P ;

Foufelle, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (24) :14767-14771

[7] The AMP-activated protein kinase - Fuel gauge of the mammalian cell? [J].

Hardie, DG ;

Carling, D .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 246 (02) :259-273

[8] The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? [J].

Hardie, DG ;

Carling, D ;

Carlson, M .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :821-855

[9] Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells - Inhibition by the AMP-activated protein kinase activation [J].

Ido, Y ;

Carling, D ;

Ruderman, N .

DIABETES, 2002, 51 (01) :159-167

[10] Prolonged Jun N-terminal kinase (JNK) activation and the upregulation of p53 and p2lWAF1/CIP1 preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin [J].

Kobayashi, K ;

Tsukamoto, I .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2001, 1537 (01) :79-88

← 1 2 3 →