Prediction of Acute Respiratory Disease in Current and Former Smokers With and Without COPD

被引：72

作者：

Bowler, Russell P. ^{[1
]}

Kim, Victor ^{[4
]}

Regan, Elizabeth ^{[1
]}

Williams, Andre A. A. ^{[1
]}

Santorico, Stephanie A. ^{[3
]}

Make, Barry J. ^{[1
]}

Lynch, David A. ^{[1
]}

Hokanson, John E. ^{[5
,6
]}

Washko, George R. ^{[7
]}

Bercz, Peter ^{[4
]}

Soler, Xavier ^{[8
]}

Marchetti, Nathaniel ^{[4
]}

Criner, Gerard J. ^{[4
]}

Ramsdell, Joe ^{[8
]}

Han, MeiLan K. ^{[9
]}

Demeo, Dawn ^{[7
]}

Anzueto, Antonio ^{[10
,11
]}

Comellas, Alejandro ^{[12
]}

Crapo, James D. ^{[1
]}

Dransfield, Mark ^{[13
]}

Wells, J. Michael ^{[13
]}

Hersh, Craig P. ^{[7
]}

MacIntyre, Neil ^{[14
]}

Martinez, Fernando ^{[9
]}

Nath, Hrudaya P. ^{[13
]}

Niewoehner, Dennis ^{[15
]}

Sciurba, Frank ^{[16
]}

Sharafkhaneh, Amir ^{[17
]}

Silverman, Edwin K. ^{[7
]}

van Beek, Edwin J. R. ^{[18
]}

Wilson, Carla ^{[2
]}

Wendt, Christine ^{[15
]}

Wise, Robert A. ^{[19
]}

机构：

[1] Natl Jewish Hlth, Dept Med, Denver, CO 80206 USA

[2] Natl Jewish Hlth, Div Biostat & Bioinformat, Denver, CO 80206 USA

[3] Univ Colorado Denver, Dept Math & Stat Sci, Denver, CO USA

[4] Temple Univ, Sect Pulm & Crit Care Med, Dept Med, Philadelphia, PA 19122 USA

[5] Univ Colorado, Dept Med, Aurora, CO USA

[6] Univ Colorado, Dept Epidemiol, Aurora, CO USA

[7] Brigham & Womens Hosp, Dept Med, Div Pulm & Crit Care, Channing Div Network Med, Boston, MA 02115 USA

[8] Univ Calif San Diego, Dept Med, Div Pulm & Crit Care Med, La Jolla, CA 92093 USA

[9] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[10] Univ Texas Hlth Sci Ctr San Antonio, Div Pulm & Crit Care Med, Dept Med, San Antonio, TX 78229 USA

[11] South Texas Vet Hlth Care Syst, San Antonio, TX USA

[12] Univ Iowa, Iowa City, IA USA

[13] Univ Alabama Birmingham, Birmingham, AL USA

[14] Duke Univ, Med Ctr, Durham, NC USA

[15] Univ Minnesota, Minneapolis, MN USA

[16] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[17] Baylor Coll Med, Houston, TX 77030 USA

[18] Univ Edinburgh, Clin Res Imaging Ctr, Edinburgh, Midlothian, Scotland

[19] Johns Hopkins Univ, Baltimore, MD USA

来源：

CHEST | 2014年 / 146卷 / 04期

基金：

美国国家卫生研究院;

关键词：

GASTROESOPHAGEAL-REFLUX SYMPTOMS; QUALITY-OF-LIFE; FAMILIAL AGGREGATION; ACUTE EXACERBATIONS; GENDER-DIFFERENCES; LUNG-FUNCTION; PULMONARY; PREVALENCE; HEALTH; RISK;

D O I：

10.1378/chest.13-2946

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

BACKGROUND: The risk factors for acute episodes of respiratory disease in current and former smokers who do not have COPD are unknown. METHODS: Eight thousand two hundred forty-six non-Hispanic white and black current and former smokers in the Genetic Epidemiology of COPD (COPDGene) cohort had longitudinal follow-up (LFU) every 6 months to determine acute respiratory episodes requiring antibiotics or systemic corticosteroids, an ED visit, or hospitalization. Negative binomial regression was used to determine the factors associated with acute respiratory episodes. A Cox proportional hazards model was used to determine adjusted hazard ratios (HRs) for time to first episode and an acute episode of respiratory disease risk score. RESULTS: At enrollment, 4,442 subjects did not have COPD, 658 had mild COPD, and 3,146 had moderate or worse COPD. Nine thousand three hundred three acute episodes of respiratory disease and 2,707 hospitalizations were reported in LFU (3,044 acute episodes of respiratory disease and 827 hospitalizations in those without COPD). Major predictors included acute episodes of respiratory disease in year prior to enrollment (HR, 1.20; 95% CI, 1.15-1.24 per exacerbation), airflow obstruction (HR, 0.94; 95% CI, 0.91-0.96 per 10% change in % predicted FEV1), and poor health-related quality of life (HR, 1.07; 95% CI, 1.06-1.08 for each 4-unit increase in St. George's Respiratory Questionnaire score). Risks were similar for those with and without COPD. CONCLUSIONS: Although acute episode of respiratory disease rates are higher in subjects with COPD, risk factors are similar, and at a population level, there are more episodes in smokers without COPD.

引用

页码：941 / 950

页数：10

共 39 条

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PREVALENCE OF BENIGN ESOPHAGEAL DISEASE IN THE DANISH POPULATION WITH SPECIAL REFERENCE TO PULMONARY-DISEASE [J].