Odontoblasts in the Dental Pulp Immune Response

被引:107
作者
Farges, Jean-Christophe [1 ,2 ,3 ]
Keller, Jean-Francois [1 ,2 ]
Carrouel, Florence [1 ,2 ]
Durand, Stephanie H. [1 ,2 ]
Romeas, Annick [1 ,2 ]
Bleicher, Francoise [1 ,2 ]
Lebecque, Serge [4 ]
Staquet, Marie-Jeanne [1 ,2 ]
机构
[1] Fac Odontol, Inst Federatif Biosci Gerland Lyon Sud, F-69372 Lyon 08, France
[2] Univ Lyon 1, Ecole Normale Super Lyon, CNRS, INRA,Inst Genom Fonct Lyon,Equipe Odontoblastes &, F-69365 Lyon, France
[3] Hosp Civils Lyon, Serv Consultat & Traitements Dent, Lyon, France
[4] Univ Lyon 1, Fac Med Grange Blanche, F-69365 Lyon, France
关键词
TOLL-LIKE RECEPTORS; NECROSIS-FACTOR-ALPHA; FACTOR-KAPPA-B; DENDRITIC CELLS; HOST-DEFENSE; RESTORATIVE DENTISTRY; CHEMOKINE SYSTEM; GENE-EXPRESSION; POSITIVE CELLS; UP-REGULATION;
D O I
10.1002/jez.b.21259
中图分类号
Q [生物科学];
学科分类号
090105 [作物生产系统与生态工程];
摘要
Recent studies have demonstrated that human dental pulp cells sense pathogens and elicit innate and/or adaptive immunity. Particular attention has been paid to odontoblasts that are situated at the pulp-dentin interface and constitute the first line of defense to cariogenic bacteria entering dentin after enamel disruption. In this review, recent in vitro and in vivo data suggesting that odontoblasts initiate immune/inflammatory events within the dental pulp in response to cariogenic bacteria are discussed. These data include sensing of pathogens by Toll-like receptors (TLRs), production of chemokines upon cell stimulation with microbial by-products and induction of dendritic cell migration. Additional results presented here reveal that all TLR genes are expressed in the healthy human dental pulp that is thus well equipped to combat pathogens entering the tissue. Seventeen chemokine genes including CXCL12, CCL2, CXCL9, CX3CL1, CCL8, CXCL10, CCL16, CCL5, CXCL2, CCL4, CXCL11 and CCL3, and 9 chemokine receptor genes including CXCR4, CCR1, CCR5, CX3CR1, CCR10 and CXCR3, are also expressed in pulp. TLR2, CCL2 and CXCL1 are upregulated in odontoblasts both under caries lesions and upon stimulation with pathogen by-products. These molecules thus appear as preferential targets for the design of therapeutic agents able to reduce the immune/inflammatory response to cariogenic bacteria and favor pulp healing. J. Exp. Zool. (Mol. Dev. Evol.) 312B:425-436, 2009. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码:425 / 436
页数:12
相关论文
共 95 条
[1]
Caries-related bacteria and cytokines induce CXCL10 in dental pulp [J].
Adachi, T. ;
Nakanishi, T. ;
Yumoto, H. ;
Hirao, K. ;
Takahashi, K. ;
Mukai, K. ;
Nakae, H. ;
Matsuo, T. .
JOURNAL OF DENTAL RESEARCH, 2007, 86 (12) :1217-1222
[2]
Pathogen recognition and innate immunity [J].
Akira, S ;
Uematsu, S ;
Takeuchi, O .
CELL, 2006, 124 (04) :783-801
[3]
Toll-like receptor signalling [J].
Akira, S ;
Takeda, K .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511
[4]
Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors [J].
Albiger, B. ;
Dahlberg, S. ;
Henriques-Normark, B. ;
Normark, S. .
JOURNAL OF INTERNAL MEDICINE, 2007, 261 (06) :511-528
[5]
Chemokine: Receptor structure, interactions, and antagonism [J].
Allen, Samantha J. ;
Crown, Susan E. ;
Handel, Tracy M. .
ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 :787-820
[6]
TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: Transcriptional activation of I kappa B alpha [J].
Arsura, M ;
Wu, M ;
Sonenshein, GE .
IMMUNITY, 1996, 5 (01) :31-40
[7]
Chemokines: more than just road signs [J].
Bachmann, MF ;
Kopf, M ;
Marsland, BJ .
NATURE REVIEWS IMMUNOLOGY, 2006, 6 (02) :159-164
[8]
Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome [J].
Belperio, JA ;
Keane, MP ;
Burdick, MD ;
Gomperts, B ;
Xue, YY ;
Hong, K ;
Mestas, J ;
Ardehali, A ;
Mehrad, B ;
Saggar, R ;
Lynch, JP ;
Ross, DJ ;
Strieter, RM .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (05) :1150-1162
[9]
Innate immunity: an overview [J].
Beutler, B .
MOLECULAR IMMUNOLOGY, 2004, 40 (12) :845-859
[10]
Bikfalvi A, 2004, SEMIN THROMB HEMOST, V30, P137