Radioactivity-Synchronized Fluorescence Enhancement Using a Radionuclide Fluorescence-Quenched Dye

被引：26

作者：

Berezin, Mikhail Y. ^{[1
]}

Guo, Kevin ^{[1
]}

Teng, Bao ^{[2
]}

Edwards, W. Barry ^{[1
]}

Anderson, Carolyn J. ^{[1
]}

Vasalatiy, Olga ^{[2
]}

Gandjbakhche, Amir ^{[3
]}

Griffiths, Gary L. ^{[2
]}

Achilefu, Samuel ^{[1
,4
]}

机构：

[1] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA

[2] NHLBI, Imaging Probe Dev Ctr, NIH, Bethesda, MD 20892 USA

[3] Eunice Shriver NICHD, Phys Biol Program, NIH, Bethesda, MD 20892 USA

[4] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 26期

关键词：

ENERGY-TRANSFER; COPPER; SENSOR; HEAVY;

D O I：

10.1021/ja903685b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate the first evidence of radioactivity-synchronized fluorescence quenching of a near-infrared tight-emitting dye by a radionuclide, Cu-64, and subsequent fluorescence enhancement upon Cu-64 decay to the daughter isotopes Ni-64 and Zn-64. The dynamic switch from high radioactivity and low fluorescence to Low radioactivity and high fluorescence is potentially useful for developing complementary multimodal imaging and detection platforms for chemical, environmental, and biomedical applications as well as for unraveling the mechanisms of meta-induced dynamic fluorescence changes.

引用

页码：9198 / +

页数：5

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