Synthetic vaccine against foot and mouth disease based on a palmitoyl derivative of the VP1 protein 135-159 fragment of the A(22) virus strain

被引：21

作者：

Volpina, OM ^{[1
]}

Yarov, AV ^{[1
]}

Zhmak, MN ^{[1
]}

Kuprianova, MA ^{[1
]}

Chepurkin, AV ^{[1
]}

Toloknov, AS ^{[1
]}

Ivanov, VT ^{[1
]}

机构：

[1] NATL RES INST ANIM HLTH,VLADIMIR 600900,YUREVETS,RUSSIA

来源：

VACCINE | 1996年 / 14卷 / 14期

关键词：

foot-and-mouth disease; peptide vaccine; veterinary use;

D O I：

10.1016/S0264-410X(96)00038-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The peptide Palm(2)135-159, a dipalmitoyl derivative of the 135-159 fragment of VP1 protein of the foot-and-mouth disease virus strain A(22) was synthesized. In the experiments on mice, guinea pigs and sheep Palm(2)135-159 possesses greater immunogenic and protective activity than the nonacylated 135-159 peptide. The synthetic vaccine against foot-and-mouth disease for toe in sheep was developed on the basis of the lipopeptide. Synthetic polymethylsiloxane oil was found to be a suitable adjuvant for this vaccine. The dependencies of protective and immunogenic effects from the dose of peptide were studied. The vaccine was found to be stable to storage for 1 year at 18 degrees C. It was shown that the synthetic vaccine provides 1 year protection of sheep against foot-and-mouth disease after a single administration. The vaccine is allowed for veterinary use in Russia. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：1375 / 1380

页数：6

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