Nonmyeloablative allogeneic immunotherapy for solid tumors

被引：23

作者：

Childs, RW ^{[1
]}

Barrett, J ^{[1
]}

机构：

[1] NHLBI, Allogene Hematopoiet Cell Transplant Unit, Hematol Branch, NIH, Bethesda, MD 20892 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2004年 / 55卷

关键词：

allogeneic stem cell transplantation; nonmyeloablative transplant; graft-versus-tumor; graft-versus-leukemia; renal cell carcinoma;

D O I：

10.1146/annurev.med.55.091902.104511

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Over the past decade, considerable advances have been made in the field of allogeneic hematopoietic stem cell transplantation. Recognition that transplanted donor immune cells can cure patients with leukemia has led to the development of nonmyeloablative or "low-intensity" conditioning regimens, which have expanded the application of allogeneic transplantation to a growing number of hematological malignancies. The improved safety and preliminary success of this transplant approach have justified applying allogeneic immunotherapy to patients with treatment-refractory solid tumors.

引用

页码：459 / 475

页数：17

共 78 条

[1] Selective depletion of donor alloreactive T cells without loss of antiviral or antileukernic responses [J].

Amrolia, PJ ;

Muccioli-Casadei, G ;

Yvon, E ;

Huls, H ;

Sili, U ;

Wieder, ED ;

Bollard, C ;

Heslop, HE ;

Molldrem, JJ ;

Rooney, CM ;

Brenner, MK .

BLOOD, 2003, 102 (06) :2292-2299

[2] Haematopoietic cell transplantation as immunotherapy [J].

Appelbaum, FR .

NATURE, 2001, 411 (6835) :385-389

[3] Non-myeloablative stem cell transplants [J].

Barrett, J ;

Childs, R .

BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (01) :6-17

[4] Ovarian cancer - Allogeneic hematopoietic stem cell transplantation in ovarian carcinoma: results of five patients [J].

Bay, JO ;

Fleury, J ;

Choufi, B ;

Tournilhac, O ;

Vincent, C ;

Bailly, C ;

Dauplat, J ;

Viens, P ;

Faucher, C ;

Blaise, D .

BONE MARROW TRANSPLANTATION, 2002, 30 (02) :95-102

[5] Potential allogeneic graft-versus-tumor effect in a patient with ovarian cancer [J].

Bay, JO ;

Choufi, B ;

Pomel, C ;

Dauplat, J ;

Durando, X ;

Tournilhac, O ;

Travade, P ;

Plagne, R ;

Blaise, D .

BONE MARROW TRANSPLANTATION, 2000, 25 (06) :681-682

[6] Graft-versus-tumour and graft-versus-leukaemia effect in patient with concurrent breast cancer and acute myelocytic leukaemia [J].

BenYosef, R ;

Or, R ;

Nagler, A ;

Slavin, S .

LANCET, 1996, 348 (9036) :1242-1243

[7] Tumor antigens recognized by T cells [J].

Boon, T ;

Coulie, PG ;

VandenEynde, B .

IMMUNOLOGY TODAY, 1997, 18 (06) :267-268

[8] Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer [J].

Bregni, M ;

Dodero, A ;

Peccatori, J ;

Pescarollo, A ;

Bernardi, M ;

Sassi, I ;

Voena, C ;

Zaniboni, A ;

Bordignon, C ;

Corradini, P .

BLOOD, 2002, 99 (11) :4234-4236

[9] The apparent disappearance of pulmonary metastasis in a case of hypernephroma following nephrectomy [J].

Bumpus, HC .

JOURNAL OF UROLOGY, 1928, 20 (02) :185-191

[10] Harnessing graft-versus-malignancy: Non-myeloablative preparative regimens for allogeneic haematopoietic transplantation, an evolving strategy for adoptive immunotherapy [J].

Champlin, R ;

Khouri, I ;

Shimoni, A ;

Gajewski, J ;

Kornblau, S ;

Molldrem, J ;

Ueno, N ;

Giralt, S ;

Anderlini, P .

BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (01) :18-29

← 1 2 3 4 5 6 7 8 →