Painful Bladder Syndrome: An Update and Review of Current Management Strategies

被引:20
作者
Dyer, Anthony J. [1 ]
Twiss, Christian O. [1 ]
机构
[1] Univ Arizona, Med Ctr, Dept Surg, Urol Sect, Tucson, AZ 85724 USA
关键词
Interstitial Cystitis; Bladder Pain Syndrome; Chronic Pelvic Pain; OralTreatment; Intravesical Treatment; Surgery; PENTOSAN POLYSULFATE SODIUM; REFRACTORY INTERSTITIAL CYSTITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; NERVE GROWTH-FACTOR; TOXIN-A INJECTIONS; BOTULINUM-TOXIN; SYNDROME/INTERSTITIAL CYSTITIS; SACRAL NEUROMODULATION; HYPERBARIC-OXYGEN; DOUBLE-BLIND;
D O I
10.1007/s11934-013-0384-z
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
100201 [内科学]; 100221 [泌尿外科学];
摘要
Interstitial cystitis/painful bladder syndrome (IC/PBS) remains a prevalent, but untreated disease with a poorly understood pathophysiology. Nonetheless, four main processes currently appear to be involved in producing IC/PBS symptoms: (1) disruption of the bladder GAG/proteoglycan layer, (2) upregulated immune/inflammatory response, (3) neural upregulation, and (4) pelvic floor dysfunction. Current and emerging therapies aimed at these potential targets will be the focus of this review with an update on IC/PBS therapy.
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页数:10
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