Preparation and characterization of poly (ethylene glycol)-coated Stober silica nanoparticles for biomedical applications

被引：3

作者：

Kopelman, R ^{[1
]}

Xu, H ^{[1
]}

Yan, F ^{[1
]}

Monson, EE ^{[1
]}

Tang, W ^{[1
]}

Schneider, R ^{[1
]}

Philbert, MA ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

BIOMEDICAL NANOTECHNOLOGY ARCHITECTURES AND APPLICATIONS | 2002年 / 4626卷

关键词：

PEG; silica nanoparticles; biocompatibility; and biomedical applications;

D O I：

10.1117/12.472104

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Monodisperse, spherical, polyethylene glycol (PEG)-coated silica nanoparticles have been prepared in the size range of 50-350 nm, and their size and size distribution were characterized by SEM and multi-angle static light scattering experiments. The chemical binding of PEG to the silica nanoparticles was confirmed by infrared spectroscopy. The biocompatibility of these PEGylated nanoparticles was also studied by non-specific protein binding tests and in-vivo toxicology studies in live animals. These silica nanoparticles, as a matrix for encapsulation of certain reagents, have been used for the fabrication of intracellular sensors and have potential for applications to in vivo diagnosis, analysis and measurements, due to their small physical size and their biocompatibility, both stemming from the specialized PEG coating.

引用

页码：383 / 393

页数：11

共 28 条

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