Sphingolipids in cancer: Regulation of pathogenesis and therapy

被引：68

作者：

Ogretmen, Besim ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Biochem & Mol Biol, Hollings Canc Ctr, Charleston, SC 29425 USA

来源：

FEBS LETTERS | 2006年 / 580卷 / 23期

关键词：

sphingolipid; ceramide; sphingosine; cancer; pathogenesis; chemotherapy; drug resistance; chemoprevention;

D O I：

10.1016/j.febslet.2006.08.052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingolipids are known to play important roles in the regulation of cell proliferation, response to chemotherapeutic agents, and/or prevention of cancer. Recently, significant progress has been made in the identification of the enzymes and their biochemical functions involved in sphingolipid metabolism. In addition, development of new techniques for the quantitative analysis of sphingolipids at their physiological levels has facilitated studies to examine distinct functions of these bioactive sphingolipids in cancer pathogenesis and therapy. This review will focus on the recent developments regarding the roles of bioactive sphingolipids in the regulation of cell growth/proliferation, and anti-cancer therapeutics. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：5467 / 5476

页数：10

共 134 条

[1] High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation [J].

Akao, Y ;

Banno, Y ;

Nakagawa, Y ;

Hasegawa, N ;

Kim, TJ ;

Murate, T ;

Igarashi, Y ;

Nozawa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 342 (04) :1284-1290

[2] Dictyostelium discoideum to human cells: Pharmacogenetic studies demonstrate a role for sphingolipids in chemoresistance [J].

Alexander, S ;

Min, JX ;

Alexander, H .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 1760 (03) :301-309

[3] Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis [J].

Argraves, KM ;

Wilkerson, BA ;

Argraves, WS ;

Fleming, PA ;

Obeid, LM ;

Drake, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (48) :50580-50590

[4] Mechanisms for the prevention of gastrointestinal cancer:: The role of prostaglandin E2 [J].

Backlund, MG ;

Mann, JR ;

DuBois, RN .

ONCOLOGY, 2005, 69 :28-32

[5] The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity [J].

Bandhuvula, P ;

Tam, YY ;

Oskouian, B ;

Saba, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (40) :33697-33700

[6] Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells:: role of Bcl-2 expression [J].

Bektas, M ;

Jolly, PS ;

Müller, C ;

Eberle, R ;

Spiegel, S ;

Geilen, CC .

ONCOGENE, 2005, 24 (01) :178-187

[7] N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells [J].

Bieberich, E ;

Kawaguchi, T ;

Yu, RK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (01) :177-181

[8] Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases [J].

Billich, A ;

Bornancin, F ;

Dévay, P ;

Mechtcheriakova, D ;

Urtz, N ;

Baumruker, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (48) :47408-47415

[9]

BOREK C, 1993, BASIC LIFE SCI, V61, P367

[10] FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function [J].

Brinkmann, V ;

Cyster, JG ;

Hla, T .

AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (07) :1019-1025

← 1 2 3 4 5 6 7 8 9 10 →