Prior meningococcal A/C polysaccharide vaccine does not reduce immune responses to conjugate vaccine in young adults

被引：13

作者：

Lakshman, R ^{[1
]}

Burkinshaw, R ^{[1
]}

Choo, S ^{[1
]}

Finn, A ^{[1
]}

机构：

[1] Sheffield Childrens Hosp, Sheffield Inst Vaccine Studies, Sheffield S10 2TH, S Yorkshire, England

来源：

VACCINE | 2002年 / 20卷 / 31-32期

关键词：

meningococcal vaccine; adult; immunogenicity;

D O I：

10.1016/S0264-410X(02)00318-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune responses induced in young adults by a meningococcal A/C polysaccharide-diphtheria toxoid conjugate vaccine (Mcj) and a meningococcal A/C plain polysaccharide vaccine (Mps) were evaluated in unvaccinated subjects and those who had received either vaccine previously. 195 subjects aged 17-30 years received either Mps or Mcj. After 12 months, they were randomised again to receive a second dose of either vaccine. Serogroup, specific serum bactericidal assay (SBA) titers and IgG antibody responses were assayed before and 4-8 weeks after primary and booster immunisation. Both vaccines were immunogenic in previously unvaccinated subjects. Administration of a dose of Mps after previous Mps or Mcj induced lower bactericidal titers to group C Neisseria meningitidis than those seen after a single dose of Mps. Bactericidal antibody responses to Mcj were not reduced in subjects who had previously received Mps. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3778 / 3782

页数：5

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