Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia

被引：109

作者：

Rubins, JB

Pomeroy, C

机构：

[1] VET ADM MED CTR,DIV INFECT DIS,MINNEAPOLIS,MN 55417

[2] UNIV MINNESOTA,DEPT MED,MINNEAPOLIS,MN 55455

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 07期

关键词：

D O I：

10.1128/IAI.65.7.2975-2977.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gamma interferon (IFN-gamma) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-gamma concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-gamma gene knockout mice, suggesting a protective role for IFN-gamma in host response to pneumococcal disease.

引用

收藏

页码：2975 / 2977

页数：3

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