Absence of Deleterious Palladin Mutations in Patients with Familial Pancreatic Cancer

被引：29

作者：

Klein, Alison P. ^{[3
,4
]}

Borges, Michael ^{[1
]}

Griffith, Margaret ^{[1
]}

Brune, Kieran ^{[1
]}

Hong, Seung-Mo ^{[1
]}

Omura, Noriyuki ^{[1
]}

Hruban, Ralph H. ^{[1
,3
]}

Goggins, Michael ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[4] Johns Hopkins Med Inst, Sol Goldman Pancreat Res Ctr, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2009年 / 18卷 / 04期

关键词：

POLY(ADP-RIBOSE) POLYMERASE; HIGH-RISK; HISTORY; INDIVIDUALS; HEREDITARY; NEOPLASIA; KINDREDS; 4Q32-34; LOCUS; BRCA2;

D O I：

10.1158/1055-9965.EPI-09-0056

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer. (Cancer Epidemiol Biomarkers Prev 2009; 18(4):1328-30)

引用

页码：1328 / 1330

页数：3

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